Article
Use of bi-allelic insertion/deletion polymorphisms as a positive control for fetal genotyping in maternal blood: first clinical experience.
Annals of the New York Academy of Sciences - 1 Sept 2006
Page-Christiaens Godelieve C M L, Bossers Bernadette, VAN DER Schoot C Ellen, DE Haas Masja
Abstract excerpt
Amplification of fetal DNA in maternal plasma is a new way for non-invasive fetal genotyping in pregnancies at risk for disorders where the presence of a paternal DNA sequence contributes to the risk status of the fetus. We describe the use of a panel of 10 bi-allelic highly polymorphic markers to ascertain the presence and amplification of fetal DNA in case the fetus is negative for the targeted paternal...
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