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Article

Hypertonic induction of aquaporin-5: novel role of hypoxia-inducible factor-1alpha.

American journal of physiology. Cell physiology - 1 Apr 2007

Zhou Beiyun, Ann David K, Li Xian, Kim Kwang-Jin, Lin Helen, Minoo Parviz, Crandall Edward D, Borok Zea

Abstract excerpt

Aquaporin-5 (AQP5) is a water channel protein expressed on the apical surface of alveolar epithelial type I cells in distal rat lung, suggesting a role for AQP5 in regulating alveolar surface liquid tonicity and/or cell volume. We investigated the molecular mechanisms underlying hypertonic induction of AQP5 in primary rat alveolar epithelial cells (AEC). Steady-state levels of AQP5 mRNA and protein were increased...

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Source

Identifiers

PMID: 17108010
DOI: 10.1152/ajpcell.00070.2006

Genes

AQP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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