Article
Comparison of PrASE and Pyrosequencing for SNP Genotyping.
BMC genomics - 16 Nov 2006
Käller Max, Hultin Emilie, Holmberg Kristina, Persson Marie-Louise, Odeberg Jacob, Lundeberg Joakim, Ahmadian Afshin
Abstract excerpt
BACKGROUND: There is an imperative need for SNP genotyping technologies that are cost-effective per sample with retained high accuracy, throughput and flexibility. We have developed a microarray-based technique and compared it to Pyrosequencing. In the protease-mediated allele-specific extension (PrASE), the protease constrains the elongation reaction and thus prevents incorrect nucleotide incorporation to...
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