Article
Large-scale genotyping of single nucleotide polymorphisms by Pyrosequencingtrade mark and validation against the 5'nuclease (Taqman((R))) assay.
Human mutation - 1 Apr 2002
Nordfors Louise, Jansson Mårten, Sandberg Gunnar, Lavebratt Catharina, Sengul Selim, Schalling Martin, Arner Peter
Abstract excerpt
Here we present the first large-scale effort at genotyping using a novel sequencing method, Pyrosequencingtrade mark, as a method for genotyping of single nucleotide polymorphisms (SNPs). Pyrosequencingtrade mark genotypes were validated through duplicate analysis of 1,022 genotypes using the PSQ96trade mark instrument for pyrosequencing and TaqMan((R)) for 5'nuclease assays. Identical results were obtained using...
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