Cyclosporine A metabolism by cytochrome P-450III occurs in microsomes from rat liver but not from normal epidermis or psoriatic lesions.

doi:10.1111/1523-1747.ep12474524

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Article

Cyclosporine A metabolism by cytochrome P-450III occurs in microsomes from rat liver but not from normal epidermis or psoriatic lesions.

The Journal of investigative dermatology - 1 Jun 1991

Duell E, Fischer V, Fisher G, Astrom A, Voorhees J

Abstract excerpt

Cyclosporine A is efficacious in the treatment of psoriasis when taken orally or injected intralesionally but not topically. Lack of penetration to necessary locations or rapid metabolism during passage through the epidermis may account for the ineffectiveness. Cytochromes P-450III in the liver are known to be involved in cyclosporine metabolism and inactivation. This study was undertaken to determine if an...

Topics

Animals
Base Sequence
Cyclosporins
Enzyme Induction
Epidermis
Erythromycin
Keratinocytes
Microsomes
Microsomes, Liver
Molecular Sequence Data
NADPH-Ferrihemoprotein Reductase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polymerase Chain Reaction

Psoriasis

RNA

Rats

Rats, Inbred Strains

Source

Open in PubMed

Identifiers

PMID: 1710636
DOI: 10.1111/1523-1747.ep12474524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1710636-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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