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Human Cytomegalovirus 5-Kilobase Immediate-Early RNA Is a Stable Intron

12 Nov 2004

Abstract excerpt

Immediate-early viral gene products of human cytomegalovirus (HCMV) are derived from several genomic loci and largely serve to establish a cellular environment conducive to viral replication. We have further examined an unusual immediate-early transcript known as the 5-kb RNA, concluding that it is a stable intron encoded by HCMV. The 5-kb RNA is highly AT rich in sequence and lacks open reading frames likely to...

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PMID: 15542670
DOI: 10.1128/jvi.78.23.13182-13189.2004

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