Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic analysis of LRRK2 mutations in patients with Parkinson disease.

Journal of the neurological sciences - 21 Dec 2006

Deng Hao, Le WeiDong, Guo Yi, Hunter Christine B, Xie WenJie, Huang MaoSheng, Jankovic Joseph

Abstract excerpt

In addition to the G2019S mutation in the leucine-rich repeat kinase 2 gene (LRRK2), which is particularly frequent in patients of Ashkenazi Jewish and Northern African origin, three amino acid substitutions (R1441C, R1441G, and R1441H), all at the same residue (R1441), have been identified as important genetic causes of Parkinson disease (PD). To evaluate the frequency of R1441C/G/H and G2019S mutations in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Arginine
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glycine

Share to Mutation

Share to Parkinson Disease

Share to Protein Serine-Threonine Kinases

Share to Serine

Source

Identifiers

PMID: 17097110
DOI: 10.1016/j.jns.2006.09.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic analysis of LRRK2 mutations in patients with Parkinson disease.PMID 17097110Read ↗

Parkinson's disease associated with LRRK2-R1441C mutation: Characterization and comparison with other LRRK2 mutations.Semantic proximity Read ↗

The LRRK2 G2019S mutation as the cause of Parkinson's disease in Ashkenazi Jews.Semantic proximity Read ↗

Frequency of LRRK2 mutations in early- and late-onset Parkinson disease.Semantic proximity Read ↗

Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease.Semantic proximity Read ↗

The LRRK2 G2019S mutation in Ashkenazi Jews with Parkinson disease: is there a gender effect?Semantic proximity Read ↗

LRRK2 mutations in patients with Parkinson's disease from Peru and Uruguay.Semantic proximity Read ↗

The LRRK2 G2019S mutation in a series of Argentinean patients with Parkinson's disease: clinical and demographic characteristics.Semantic proximity Read ↗

Lrrk2 pathogenic substitutions in Parkinson's disease.Semantic proximity Read ↗

LRRK2 G2019S in families with Parkinson disease who originated from Europe and the Middle East: evidence of two distinct founding events beginning two millennia ago.Semantic proximity Read ↗

Genetic screening of the G2019S mutation of the LRRK2 gene in Southwest European, North African, and Sephardic Jewish subjects.Semantic proximity Read ↗

Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain.Semantic proximity Read ↗

Haplotype analysis of Lrrk2 R1441H carriers with parkinsonism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.