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Article

Genetic analysis of LRRK2 mutations in patients with Parkinson disease.

Journal of the neurological sciences - 21 Dec 2006

Deng Hao, Le WeiDong, Guo Yi, Hunter Christine B, Xie WenJie, Huang MaoSheng, Jankovic Joseph

Abstract excerpt

In addition to the G2019S mutation in the leucine-rich repeat kinase 2 gene (LRRK2), which is particularly frequent in patients of Ashkenazi Jewish and Northern African origin, three amino acid substitutions (R1441C, R1441G, and R1441H), all at the same residue (R1441), have been identified as im...

Topics

Adult
Aged
Arginine
Chromosomes, Human, Pair 12
DNA Mutational Analysis
Female
Glycine
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Male
Middle Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parkinson Disease

Protein Serine-Threonine Kinases

Serine

Source

Identifiers

PMID: 17097110
DOI: 10.1016/j.jns.2006.09.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-17097110-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Genetic analysis of LRRK2 mutations in patients with Parkinson disease.PMID 17097110Read ↗

Parkinson's disease associated with LRRK2-R1441C mutation: Characterization and comparison with other LRRK2 mutations.Semantic proximity Read ↗

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Frequency of LRRK2 mutations in early- and late-onset Parkinson disease.Semantic proximity Read ↗

Mutations in LRRK2 other than G2019S are rare in a north American-based sample of familial Parkinson's disease.Semantic proximity Read ↗

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