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Article

No association between polymorphisms in the BDNF gene and age at onset in Huntington disease.

BMC medical genetics - 10 Nov 2006

Mai Maren, Akkad Amer D, Wieczorek Stefan, Saft Carsten, Andrich Jürgen, Kraus Peter H, Epplen Jörg T, Arning Larissa

Abstract excerpt

BACKGROUND: Recent evidence suggests that brain-derived neurotrophic factor (BDNF) is an attractive candidate for modifying age at onset (AO) in Huntington disease (HD). In particular, the functional Val66Met polymorphism appeared to exert a significant effect. Here we evaluate BDNF variability with respect to AO of HD using markers that represent the entire locus. METHODS: Five selected tagging polymorphisms...

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Source

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Identifiers

PMID: 17096834
DOI: 10.1186/1471-2350-7-79
PMCID: PMC1637098

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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No association between polymorphisms in the BDNF gene and age at onset in Huntington disease.PMID 17096834Read ↗

No evidence of association between BDNF gene variants and age-at-onset of Huntington's disease.Semantic proximity Read ↗

Association between BDNF Val66Met polymorphism and age at onset in Huntington disease.Semantic proximity Read ↗

Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease.Semantic proximity Read ↗

Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset.Semantic proximity Read ↗

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in Parkinson's disease and age of onset.Semantic proximity Read ↗

BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study.Semantic proximity Read ↗

Analysis of the 5' upstream sequence of the Huntington's disease (HD) gene shows six new rare alleles which are unrelated to the age at onset of HD.Semantic proximity Read ↗

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in schizophrenia is associated with age at onset and symptoms.Semantic proximity Read ↗

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Evaluation of Biochemical and Epigenetic Measures of Peripheral Brain-Derived Neurotrophic Factor (BDNF) as a Biomarker in Huntington’s Disease PatientsSemantic proximity Read ↗

Exploring the impact of BDNF Val66Met genotype on serotonin transporter and serotonin-1A receptor binding.Semantic proximity Read ↗

Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population.Semantic proximity Read ↗

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