Article
A bivariate functional mapping model for identifying haplotypes that control drug response for systolic and diastolic blood pressures.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2006
Lin Min, Wu Rongling, Johnson Julie
Abstract excerpt
A bivariate functional mapping model has been proposed to detect haplotype-based DNA sequence variants that regulate the response curves of systolic and diastolic blood pressures (SBP and DBP) to a particular drug. This model capitalizes on the haplotype structure constructed by single nucleotide polymorphisms (SNPs) and incorporates the mathematical aspects of pharmacodynamic reactions into the estimation...
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