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Article

Identification of the FHL2 transcriptional coactivator as a new functional target of the E7 oncoprotein of human papillomavirus type 16.

Journal of virology - 1 Jan 2007

Campo-Fernández Beatriz, Morandell Dieter, Santer Frédéric R, Zwerschke Werner, Jansen-Dürr Pidder

Abstract excerpt

We identified the transcriptional coactivator FHL2 as a novel target of the human papillomavirus type 16 (HPV-16) E7 oncoprotein, which plays a major role in cell transformation. The interaction with FHL2 is abolished by mutations in conserved regions 1 and 2 and in the C-terminal zinc finger domain of E7, all required for its transforming potential. We found that E7 impairs the coactivator function of FHL2 on...

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Source

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Identifiers

PMID: 17093190
DOI: 10.1128/JVI.01699-06
PMCID: PMC1797482

Genes

FHL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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