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Article

The role of human achaete-scute homolog-1 in medullary thyroid cancer cells.

Surgery - 1 Dec 2003

Sippel Rebecca S, Carpenter Jennifer E, Kunnimalaiyaan Muthusamy, Chen Herbert

Abstract excerpt

BACKGROUND: Human achaete-scute homolog-1 (hASH1) is a transcription factor that is expressed highly in neuroendocrine tumors such as medullary thyroid cancer (MTC). Thyroid C-cells do not develop in hASH1 knockout mice, which suggests that hASH1 is essential for normal C-cell development. METHODS: To determine the effect of raf-1 induction on hASH1 and hormone production, we used an estrogen inducible raf-1...

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Identifiers

PMID: 14668716
DOI: 10.1016/s0039-6060(03)00418-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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