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Article

MDR1 (ABCB1) gene polymorphism C3435T is associated with P-glycoprotein activity in B-cell chronic lymphocytic leukemia.

Pharmacological reports : PR - 1 Jan 2000

Jamroziak Krzysztof, Balcerczak Ewa, Smolewski Piotr, Robey Robert W, Cebula Barbara, Panczyk Mariusz, Kowalczyk Monika, Szmigielska-Kapłon Anna, Mirowski Marek, Bates Susan E, Robak Tadeusz

Abstract excerpt

Functional single nucleotide polymorphism (SNP) C3435T in exon 26 of the MDR1 ( ABCB1 ) gene encoding the xenobiotic transporter P-glycoprotein (P-gp, MDR1, ABCB1) may influence susceptibility to several diseases as well as clinical outcome of treatment with P-gp substrates. Exposure to environmental chemicals is thought to be involved in the pathogenesis of B-cell chronic lymphocytic leukemia (B-CLL) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to Drug Resistance, Multiple

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Share to Genetic Predisposition to Disease

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Identifiers

PMID: 17085864

Genes

ABCB1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MDR1 (ABCB1) gene polymorphism C3435T is associated with P-glycoprotein activity in B-cell chronic lymphocytic leukemia.PMID 17085864Read ↗

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