Article
Interference of components of the phosphoenolpyruvate phosphotransferase system with the central virulence gene regulator PrfA of Listeria monocytogenes.
Journal of bacteriology - 1 Jan 2007
Mertins Sonja, Joseph Biju, Goetz Monika, Ecke Regina, Seidel Gerald, Sprehe Mareen, Hillen Wolfgang, Goebel Werner, Müller-Altrock Stefanie
Abstract excerpt
Analysis of Listeria monocytogenes ptsH, hprK, and ccpA mutants defective in carbon catabolite repression (CCR) control revealed significant alterations in the expression of PrfA-dependent genes. The hprK mutant showed high up-regulation of PrfA-dependent virulence genes upon growth in glucose-containing medium whereas expression of these genes was even slightly down-regulated in the ccpA mutant compared to the...
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