Article
The role of glutathione-S-transferase polymorphisms in ovarian cancer survival.
European journal of cancer (Oxford, England : 1990) - 1 Jan 2007
Nagle Christina M, Chenevix-Trench Georgia, Spurdle Amanda B, Webb Penelope M
Abstract excerpt
Resistance to chemotherapy represents one of the most important causes of treatment failure in patients with ovarian cancer. Common polymorphisms in the glutathione-S-transferase (GSTM1, GSTP1 and GSTT1) family have been implicated in chemoresistence and ovarian cancer survival. In this study, we have analysed Australian women diagnosed with primary invasive epithelial ovarian cancer between 1985 and 1997, using...
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