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Article

Genetic Vulnerability of GPCRs: A Call to Action.

Trends in biochemical sciences - 1 Apr 2018

Liggett Stephen B

Abstract excerpt

G-protein-coupled receptors (GPCRs) are the targets for many drugs, but the response shows interindividual variability. The 'one-drug-fits-all' approach has been challenged by evidence showing multiple human genetic variants of GPCRs. Identification and characterization of GPCR variants must be undertaken for rational, personalized, and economically sound prescribing practices.

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Identifiers

PMID: 29605062
DOI: 10.1016/j.tibs.2018.02.006
PMCID: PMC6092946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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