Article
Epidermal growth factor receptor status in anaplastic thyroid carcinoma.
Journal of clinical pathology - 1 Aug 2007
Lee Dae Ho, Lee Geon Kook, Kong Sun-Young, Kook Myoung Chul, Yang Sun Kyung, Park So Yeon, Park Seong Hoe, Keam Bhumsuk, Park Do Joon, Cho Bo Youn, Kim Seok Won, Chung Ki-Wook, Lee Eun Sook, Kim Sun Wook
Abstract excerpt
BACKGROUND: The epidermal growth factor receptor (EGFR) has been reported to be overexpressed in anaplastic thyroid carcinoma (ATC). In vitro studies have shown that EGFR tyrosine kinase inhibitors (TKIs) greatly inhibit cellular growth and induced apoptosis in the ATC cell lines, while somatic mutations in the tyrosine kinase domain or an increased gene copy number are associated with increased sensitivity to...
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