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Article

Association of polymorphisms within the promoter region of the tumor necrosis factor-alpha with clinical outcomes of rheumatic fever.

Molecular immunology - 1 Mar 2007

Ramasawmy Rajendranath, Faé Kellen C, Spina Guilherme, Victora Gabriel D, Tanaka Ana Cristina, Palácios Selma A, Hounie Ana G, Miguel Euripides C, Oshiro Sandra E, Goldberg Anna C, Kalil Jorge, Guilherme Luiza

Abstract excerpt

Rheumatic fever (RF)/rheumatic heart disease (RHD) is an inflammatory disease with a complex etiology in which Group A streptococci within a genetically susceptible host untreated for strep-throat may deviate the innate and adaptive arms of the immune system towards recognition of autoantigens. The TNFA gene has been associated with a number of autoimmune diseases, including RF. We investigated whether the G-308A...

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Identifiers

PMID: 17079017
DOI: 10.1016/j.molimm.2006.10.001

Genes

RHD

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