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Article

TNF-alpha G-308A polymorphism is associated with rheumatic fever and correlates with increased TNF-alpha production.

Journal of autoimmunity - 1 Sept 2005

Sallakci Nilgun, Akcurin Gayaz, Köksoy Sadi, Kardelen Firat, Uguz Aysen, Coskun Mesut, Ertug Halil, Yegin Olcay

Abstract excerpt

Previous studies suggested that abnormal regulation of TNF-alpha production may have a role in the pathogenesis of rheumatic fever (RF). Polymorphism at the promoter region of TNF-alpha gene (-308 A) has recently been shown to be associated with rheumatic heart disease (RHD) in Mexican patients. Although this polymorphism has long been shown to affect TNF-alpha gene expression in cell lines, its role in...

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Identifiers

PMID: 16046099
DOI: 10.1016/j.jaut.2005.05.005

Genes

TNF
RHD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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TNF-alpha G-308A polymorphism is associated with rheumatic fever and correlates with increased TNF-alpha production.PMID 16046099Read ↗

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