Article
Influx of extracellular Ca2+ is necessary for electrotaxis in Dictyostelium.
Journal of cell science - 15 Nov 2006
Shanley Lynne J, Walczysko Petr, Bain Mary, MacEwan David J, Zhao Min
Abstract excerpt
Intracellular free Ca2+ ([Ca2+](i)) is a pivotal signalling element in cell migration and is thought to be required for chemotaxis of Dictyostelium. Ca2+ signalling may also be important for electrotaxis. However this suggestion has been controversial. We show that electric fields direct Dictyostelium cells to migrate cathodally and increase [Ca2+](i) in Dictyostelium cells, as determined by Fluo-3 AM imaging and...
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