Article
Genetic divergence of human immunodeficiency virus type 1 Ethiopian clade C reverse transcriptase (RT) and rapid development of resistance against nonnucleoside inhibitors of RT.
Antimicrobial agents and chemotherapy - 1 Jul 2002
Loemba Hugues, Brenner Bluma, Parniak Michael A, Ma'ayan Shlomo, Spira Bonnie, Moisi Daniela, Oliveira Maureen, Detorio Mervi, Wainberg Mark A
Abstract excerpt
We sequenced and phylogenetically analyzed the reverse transcriptase (RT) region of five human immunodeficiency virus type 1 isolates from treatment-naive Ethiopian émigrés to Israel. Heteroduplex mobility assays were performed to confirm the clade C status of env genomic regions. The RT sequences showed that the strains clustered phylogenetically with clade C viruses, and a KVEQ-specific motif of silent...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.