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Article

Prostate cancer risk from occupational exposure to polycyclic aromatic hydrocarbons interacting with the GSTP1 Ile105Val polymorphism.

Cancer detection and prevention - 1 Jan 2006

Rybicki Benjamin A, Neslund-Dudas Christine, Nock Nora L, Schultz Lonni R, Eklund Ludmila, Rosbolt James, Bock Cathryn H, Monaghan Kristin G

Abstract excerpt

BACKGROUND: Variation in the glutathione S-transferase (GSTP1) gene and occupational polycyclic aromatic hydrocarbons (PAH) exposure are putative prostate cancer risk factors. An Ile/Val polymorphism in codon 105 of GSTP1 affects its enzymatic activity toward PAH detoxification, a possible mechanism in prostate carcinogenesis. METHODS: To determine whether the GSTP1 Ile105Val polymorphism modifies prostate cancer...

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Identifiers

PMID: 17067754
DOI: 10.1016/j.cdp.2006.09.004
PMCID: PMC1769317

Genes

PAH
GSTP1

Provenance

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