Article
Detoxication of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione.
FEBS letters - 6 Nov 1998
Sundberg K, Seidel A, Mannervik B, Jernström B
Abstract excerpt
Epidemiological studies suggest that individuals differing in the expression of allelic variants of the human glutathione transferase (GST) Pi gene differ in susceptibility to chemical carcinogens such as polycyclic aromatic hydrocarbons (PAH). This study reports the catalytic efficiencies (k(cat...
Topics
- Carcinogens
- Catalysis
- Genetic Variation
- Glutathione
- Glutathione Transferase
- Humans
- Inactivation, Metabolic
- Kinetics
- Molecular Structure
- Polycyclic Aromatic Hydrocarbons
- Structure-Activity Relationship