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Article

A novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2006

Jiang Hong, Olson Melissa V, Medrano Diana R, Lee Ok-Hee, Xu Jing, Piao Yuji, Alonso Marta M, Gomez-Manzano Candelaria, Hung Mien-Chie, Yung W K Alfred, Fueyo Juan

Abstract excerpt

Adenoviral E1A is a versatile protein that can reprogram host cells for efficient viral replication. The nuclear import of E1A is mediated by a nuclear localization signal; however, whether E1A can be actively exported from the nucleus is unknown. We first reported a CRM1-dependent nuclear export signal (NES) in E1A that is conserved in the group C adenoviruses. We showed that CRM1 and E1A coimmunoprecipitated...

Read the complete abstract on PubMed

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Share to Active Transport, Cell Nucleus
Share to Adenovirus E1A Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exportin 1 Protein

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Share to Receptors, Cytoplasmic and Nuclear

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Source

Identifiers

PMID: 17065226
DOI: 10.1096/fj.06-6433fje

Genes

NES
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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