Article
Further insights into the tRNA modification process controlled by proteins MnmE and GidA of Escherichia coli.
Nucleic acids research - 1 Jan 2006
Yim Lucía, Moukadiri Ismaïl, Björk Glenn R, Armengod M-Eugenia
Abstract excerpt
In Escherichia coli, proteins GidA and MnmE are involved in the addition of the carboxymethylaminomethyl (cmnm) group onto uridine 34 (U34) of tRNAs decoding two-family box triplets. However, their precise role in the modification reaction remains undetermined. Here, we show that GidA is an FAD-binding protein and that mutagenesis of the N-terminal dinucleotide-binding motif of GidA, impairs capability of this...
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