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Article

Parkinsonism, Lrrk2 G2019S, and tau neuropathology.

Neurology - 24 Oct 2006

Rajput A, Dickson D W, Robinson C A, Ross O A, Dächsel J C, Lincoln S J, Cobb S A, Rajput M L, Farrer M J

Abstract excerpt

Lrrk2 G2019S is predominantly associated with alpha-synuclein-immunopositive Lewy body pathology. We have identified Family SK where Lrrk2 G2019S segregates with slowly progressive parkinsonism and the affected proband has tau-immunopositive neurofibrillary tangle pathology. Thus alpha-synucleinopathy and tauopathy, the predominant pathologies associated with parkinsonism, may be alternate outcomes of the same...

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Source

Identifiers

PMID: 17060589
DOI: 10.1212/01.wnl.0000240220.33950.0c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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