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Article

Activated PI3K signaling as an endogenous inducer of p53 in human cancer.

Cell cycle (Georgetown, Tex.) - 15 Feb 2007

Lee Carolyn, Kim Jung-Sik, Waldman Todd

Abstract excerpt

Complex pathways exist in mammalian cells to regulate the expression and activity of oncogenes and tumor suppressor genes. Defining these regulatory pathways is an important step towards being able to interfere with tumorigenesis. Here we discuss our recent study indicating that activation of the...

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Topics

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Share to Cell Line, Tumor
Share to Cell Transformation, Neoplastic
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Biological

Share to Phosphatidylinositol 3-Kinases

Share to PTEN Phosphohydrolase

Share to Signal Transduction

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 17329971
DOI: 10.4161/cc.6.4.3810
PMCID: PMC4394610

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17329971-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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