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Article

Increased HIV-1 sensitivity to neutralizing antibodies by mutations in the Env V3-coding region for resistance to CXCR4 antagonists.

The Journal of general virology - 1 Sept 2016

Hikichi Yuta, Yokoyama Masaru, Takemura Taichiro, Fujino Masayuki, Kumakura Sei, Maeda Yosuke, Yamamoto Naoki, Sato Hironori, Matano Tetsuro, Murakami Tsutomu

Abstract excerpt

HIV-1 passage in cell culture in the presence of chemokine receptor antagonists can result in selection of viruses with env mutations that confer resistance to these inhibitors. In the present study, we examined the effect of HIV-1env mutations that confer resistance to CXCR4 antagonists on envelope (Env) sensitivity to neutralizing antibodies (NAbs). Serial passage of CXCR4-tropic HIV-1 NL4-3 in PM1/CCR5 cells...

Read the complete abstract on PubMed

Topics

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Share to Adaptation, Biological
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

Share to HIV Antibodies

Share to Molecular Dynamics Simulation

Share to Mutant Proteins

Share to Receptors, CXCR4

Share to Serial Passage

Source

Identifiers

PMID: 27368421
DOI: 10.1099/jgv.0.000536

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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