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Article

Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells.

Development (Cambridge, England) - 1 Nov 2006

Asai Naoya, Fukuda Toshifumi, Wu Zaiqi, Enomoto Atsushi, Pachnis Vassilis, Takahashi Masahide, Costantini Frank

Abstract excerpt

The RET receptor tyrosine kinase plays a critical role in the development of the enteric nervous system (ENS) and the kidney. Upon glial-cell-line-derived neurotrophic factor (GDNF) stimulation, RET can activate a variety of intracellular signals, including the Ras/mitogen-activated protein kinase, phosphatidylinositol 3-kinase (PI3K)/AKT, and RAC1/JUN NH(2)-terminal kinase (JNK) pathways. We recently...

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Source

Identifiers

PMID: 17050626
DOI: 10.1242/dev.02616

Genes

RET
GDNF
RAC1
JUN
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells.PMID 17050626Read ↗

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