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Article

A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity.

PLoS genetics - 1 Nov 2016

Heanue Tiffany A, Boesmans Werend, Bell Donald M, Kawakami Koichi, Vanden Berghe Pieter, Pachnis Vassilis

Abstract excerpt

Hirschsprung disease (HSCR) is characterized by absence of enteric neurons from the distal colon and severe intestinal dysmotility. To understand the pathophysiology and genetics of HSCR we developed a unique zebrafish model that allows combined genetic, developmental and in vivo physiological studies. We show that ret mutant zebrafish exhibit cellular, physiological and genetic features of HSCR, including...

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Source

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Identifiers

PMID: 27902697
DOI: 10.1371/journal.pgen.1006439
PMCID: PMC5130169

Genes

MAPK10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Novel Zebrafish ret Heterozygous Model of Hirschsprung Disease Identifies a Functional Role for mapk10 as a Modifier of Enteric Nervous System Phenotype Severity.PMID 27902697Read ↗

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