Article
Arsenic trioxide-dependent activation of thousand-and-one amino acid kinase 2 and transforming growth factor-beta-activated kinase 1.
Molecular pharmacology - 1 May 2010
McNeer Jennifer L, Goussetis Dennis J, Sassano Antonella, Dolniak Blazej, Kroczynska Barbara, Glaser Heather, Altman Jessica K, Platanias Leonidas C
Abstract excerpt
Arsenic trioxide (As(2)O(3)) has potent antileukemic properties in vitro and in vivo, but the mechanisms by which it generates its effects on target leukemic cells are not well understood. Understanding cellular mechanisms and pathways that are activated in leukemic cells to control the generation of As(2)O(3) responses should have important implications in the development of novel approaches using As(2)O(3) for...
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