c-Jun NH2-Terminal Kinase 2α2 Promotes the Tumorigenicity of Human Glioblastoma Cells

Abstract excerpt

c-Jun NH(2)-terminal kinases (JNK) are members of the mitogen-activated protein kinase family and have been implicated in the formation of several human tumors, especially gliomas. We have previously shown that a 55 kDa JNK isoform is constitutively active in 86% of human brain tumors and then showed that it is specifically a JNK2 isoform and likely to be either JNK2alpha2 or JNK2beta2. Notably, we found that...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cellular Mechanics and Interactions
• Share to Cytokine Signaling Pathways and Interactions
• Share to Melanoma and MAPK Pathways