Article
RNF213 suppresses carcinogenesis in glioblastoma by affecting MAPK/JNK signaling pathway.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Sept 2020
Wang X, Ye M, Wu M, Fang H, Xiao B, Xie L, Zhu X
Abstract excerpt
PURPOSE: Glioblastoma is the most common malignant brain tumor in central nervous system. Due to absence of the mechanism underlying glioblastoma, the clinical outcome is poor. RNF213 is a ring finger protein and mutation in RNF213 gene is detected in cancers. But the role of RNF213 in glioblastoma is unknown. METHODS: RNF213 expression was detected by qPCR, western blotting, IHC technology. RNF213 was...
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