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Article

Dosage-dependent rescue of definitive nephrogenesis by a distant Gata3 enhancer.

Developmental biology - 15 Jan 2007

Hasegawa Susan L, Moriguchi Takashi, Rao Arvind, Kuroha Takashi, Engel James Douglas, Lim Kim-Chew

Abstract excerpt

Human GATA3 haploinsufficiency leads to HDR (hypoparathyroidism, deafness and renal dysplasia) syndrome, demonstrating that the development of a specific subset of organs in which this transcription factor is expressed is exquisitely sensitive to gene dosage. We previously showed that murine GATA-3 is essential for definitive kidney development, and that a large YAC transgene faithfully recapitulated GATA-3...

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Share to Embryo, Mammalian
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Developmental

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Source

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Identifiers

PMID: 17046739
DOI: 10.1016/j.ydbio.2006.09.030
PMCID: PMC1858647

Genes

GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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