Article
Impaired somatostatin accumulation within the median eminence in mice with mosaic mutation.
Neuro endocrinology letters - 1 Jan 2000
Wojewodzka Urszula, Gajewska Alina, Gajkowska Barbara, Styrna Jozefa, Kochman Kazimierz
Abstract excerpt
OBJECTIVES: The mosaic mutation (Atp7a(mo-ms)) linked to X-chromosome is caused by changes in the Atp7a gene encoding CPx-type protein responsible for the ATP-dependent copper transport across cell membranes. Mosaic mutant males represent an animal model for Menkes disease in humans. Starting from the eighth day of life the mosaic males exhibit a progressive decrease in body weight with poor viability and...
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