High anti-collagen type-II antibody levels and induction of proinflammatory cytokines by anti-collagen antibody-containing immune complexes in vitro characterise a distinct rheumatoid arthritis phenotype associated with acute inflammation at the time of disease onset.

Abstract excerpt

OBJECTIVE: To investigate whether the cytokine-inducing properties of surface-bound collagen type II (CII)-containing immune complexes (IC), which were reported earlier, have any clinical impact. METHODS: Anti-CII serology was analysed in 274 patients with early rheumatoid arthritis (RA). Patient...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antigen-Antibody Complex
• Share to Antirheumatic Agents