Article
Local anti-type II collagen antibody production in rheumatoid arthritis synovial fluid. Evidence for an HLA-DR4-restricted IgG response.
Arthritis and rheumatism - 1 Jul 1994
Rönnelid J, Lysholm J, Engström-Laurent A, Klareskog L, Heyman B
Abstract excerpt
OBJECTIVE: To investigate the production of type II collagen (CII) antibodies in the synovial fluid (SF) of rheumatoid arthritis (RA) patients, and to examine the HLA dependence of this local production. METHODS: The ELISPOT method was used for enumerating anti-CII-reactive cells. Serologic tissu...
Topics
- Adult
- Aged
- Alleles
- Antibody Formation
- Antibody Specificity
- Arthritis, Rheumatoid
- Collagen
- Enzyme-Linked Immunosorbent Assay
- Female
- HLA-DR Antigens
- HLA-DR4 Antigen
- Humans
- Immunoglobulin G
- Immunosorbent Techniques
- Male
- Middle Aged
- Synovial Fluid