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Deletion of theSSK1Response Regulator Gene inCandida albicansContributes to Enhanced Killing by Human Polymorphonuclear Neutrophils

21 Jan 2005

Abstract excerpt

The isolation and partial functional characterization of the two-component response regulator SSK1 gene of Candida albicans was previously reported. Compared to wild-type (CAF2-1) and gene-reconstituted (SSK23) strains, the ssk1 null strain (SSK21) was avirulent in a murine model of hematogenously disseminated candidiasis and less able to adhere to human esophageal cells. More recent data indicate that SSK21 is...

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PMID: 15664927
DOI: 10.1128/iai.73.2.865-871.2005

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