Quantitative Analysis of<i>tpr</i>Gene Expression in<i>Treponema pallidum</i>Isolates: Differences among Isolates and Correlation with T-Cell Responsiveness in Experimental Syphilis

Abstract excerpt

Transcriptional analysis of the tpr genes in Treponema pallidum subsp. pallidum (referred to here as simply T. pallidum) has been limited to date, and yet the expression of members of this gene family is likely relevant to the pathogenesis of syphilis. Recently, immunological studies and semiquantitative mRNA analysis led to the hypothesis of the modulation of tpr gene transcription during infection and suggested...

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