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Article

COL1A1, COL4A3, TIMP2 and TGFB1 polymorphisms in cervical insufficiency.

Journal of perinatal medicine - 25 Jun 2021

Alves Ana Paula V D, Freitas Amanda B, Levi José Eduardo, Amorim Filho Antonio G, Franco Lucas A M, Hoshida Mara Sandra, Patiño Elizabeth G, Francisco Rossana P V, Carvalho Mario Henrique B

Abstract excerpt

OBJECTIVES: To investigate the association between selected single nucleotide polymorphisms (SNPs) with cervical insufficiency and its relationship with obstetric history. METHODS: Twenty-eight women with cervical insufficiency (case group) and 29 non-pregnant women (control group) were included. The SNPs sequenced included rs2586490 in collagen type I alpha 1 chain (COL1A1), rs1882435 in collagen type IV alpha 3...

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PMID: 33550735
DOI: 10.1515/jpm-2020-0320

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