Article
Analysis of protein sequence and interaction data for candidate disease gene prediction.
Nucleic acids research - 1 Jan 2006
George Richard A, Liu Jason Y, Feng Lina L, Bryson-Richardson Robert J, Fatkin Diane, Wouters Merridee A
Abstract excerpt
Linkage analysis is a successful procedure to associate diseases with specific genomic regions. These regions are often large, containing hundreds of genes, which make experimental methods employed to identify the disease gene arduous and expensive. We present two methods to prioritize candidates for further experimental study: Common Pathway Scanning (CPS) and Common Module Profiling (CMP). CPS is based on the...
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