Article
Analysis of genome-wide association study data using the protein knowledge base.
BMC genetics - 13 Nov 2011
Ballouz Sara, Liu Jason Y, Oti Martin, Gaeta Bruno, Fatkin Diane, Bahlo Melanie, Wouters Merridee A
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) aim to identify causal variants and genes for complex disease by independently testing a large number of SNP markers for disease association. Although genes have been implicated in these studies, few utilise the multiple-hit model of complex disease to identify causal candidates. A major benefit of multi-locus comparison is that it compensates for some...
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