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Article

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.

PLoS medicine - 1 Oct 2006

Weedon Michael N, McCarthy Mark I, Hitman Graham, Walker Mark, Groves Christopher J, Zeggini Eleftheria, Rayner N William, Shields Beverley, Owen Katharine R, Hattersley Andrew T, Frayling Timothy M

Abstract excerpt

BACKGROUND: A limited number of studies have assessed the risk of common diseases when combining information from several predisposing polymorphisms. In most cases, individual polymorphisms only moderately increase risk (approximately 20%), and they are thought to be unhelpful in assessing individuals' risk clinically. The value of analyzing multiple alleles simultaneously is not well studied. This is often...

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Source

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Identifiers

PMID: 17020404
DOI: 10.1371/journal.pmed.0030374
PMCID: PMC1584415

Genes

KCNJ11
PPARG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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