Genetic variability, molecular evolution, and geographic diversity of HLA-B27.

doi:10.1016/s0198-8859(01)00299-3

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Article

Genetic variability, molecular evolution, and geographic diversity of HLA-B27.

Human immunology - 1 Sept 2001

Blanco-Gelaz M A, López-Vázquez A, García-Fernández S, Martínez-Borra J, González S, López-Larrea C

Abstract excerpt

HLA-B27 represents a family of 23 closely related alleles (B*2701-23) that differ at 24 amino acid positions. The pattern of polymorphisms of B27 was studied, with special reference to synonymous (Ks) and nonsynonymous (Ka) divergence among alleles. B27 alleles are characterized by the enhanced rate of nonsynonymous nucleotide substitution in the peptide-binding region (PBR). The percentage of substitutions...

Topics

Africa
Amino Acid Substitution
Asia
Asia, Southeastern
Asian People
Europe
Evolution, Molecular
Genetic Variation
HLA-B27 Antigen
Haplotypes
Humans
Indians, North American
Phylogeny
Polymorphism, Genetic
Polynesia
Recombination, Genetic
Selection, Genetic
White People

Source

Open in PubMed

Identifiers

PMID: 11543905
DOI: 10.1016/s0198-8859(01)00299-3

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