Article
CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.
Oncogene - 8 Jan 2009
Smalley K S M, Xiao M, Villanueva J, Nguyen T K, Flaherty K T, Letrero R, Van Belle P, Elder D E, Wang Y, Nathanson K L, Herlyn M
Abstract excerpt
Here, we identify a panel of melanoma lines with non-V600E mutations in BRAF. These G469E- and D594G-mutated melanomas were found to exhibit constitutive levels of phospho-extracellular signal-regulated kinase (pERK) and low levels of phospho-mitogen-activated protein kinase/ERK kinase (pMEK) and were resistant to MEK inhibition. Upon treatment with the CRAF inhibitor sorafenib, these lines underwent apoptosis...
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