Article
Primary glomerulonephritis with isolated C3 deposits: a new entity which shares common genetic risk factors with haemolytic uraemic syndrome.
Journal of medical genetics - 1 Mar 2007
Servais Aude, Frémeaux-Bacchi Véronique, Lequintrec Moglie, Salomon Rémi, Blouin Jacques, Knebelmann Bertrand, Grünfeld Jean-Pierre, Lesavre Philippe, Noël Laure-Hélène, Fakhouri Fadi
Abstract excerpt
INTRODUCTION: Abnormal control of the complement alternative pathway (CAP) (factor H, factor I and membrane cofactor protein (MCP) deficiencies) is a well established risk factor for the occurrence of haemolytic uraemic syndrome (HUS). In some instances, HUS may be associated with an unusual glomerulonephritis with isolated C3 deposits (glomerulonephritis C3). We determined whether HUS and glomerulonephritis C3...
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