Article
Genetic impact of functional single nucleotide polymorphisms in the 3'-UTR region of the chemoattractant receptor expressed on Th2 cells (CRTH2) gene on asthma and atopy in a Japanese population.
International archives of allergy and immunology - 1 Jan 2007
Maeda Yukiko, Hizawa Nobuyuki, Takahashi Daisuke, Fukui Yoshinobu, Konno Satoshi, Nishimura Masaharu
Abstract excerpt
BACKGROUND: The human chemoattractant receptor expressed on Th2 cells (CRTH2), the receptor for prostaglandin D2, induces cell migration in eosinophils, basophils, and Th2 cells. The gene encoding CRTH2 is located on chromosome 11q13. Several groups, including ours, have reported significant associations between this region and various traits associated with allergic diseases such as asthma and atopy. Two single...
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