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Article

Functional expression of a single-chain antibody to ErbB-2 in plants and cell-free systems

1 Jun 2006

Abstract excerpt

BACKGROUND: Aberrant signaling by ErbB-2 (HER 2, Neu), a member of the human Epidermal Growth Factor (EGF) receptor family, is associated with an aggressive clinical behaviour of carcinomas, particularly breast tumors. Antibodies targeting the ErbB-2 pathway are a preferred therapeutic option for patients with advanced breast cancer, but a worldwide deficit in the manufacturing capacities of mammalian cell...

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PMID: 17010186
DOI: 10.1186/1479-5876-4-39

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