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Article

High-level secretion of recombinant monomeric murine and human single-chain Fv antibodies from Drosophila S2 cells

12 Dec 2011

Abstract excerpt

Single-chain variable fragment (scFvs) antibodies are small polypeptides (∼26 kD) containing the heavy (V(H)) and light (V(L)) immunoglobulin domains of a parent antibody connected by a flexible linker. In addition to being frequently used in diagnostics and therapy for an increasing number of human diseases, scFvs are important tools for structural biology as crystallization chaperones. Although scFvs can be...

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PMID: 22160929
DOI: 10.1093/protein/gzr058

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