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Article

SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda.

The Journal of investigative dermatology - 1 Feb 2007

Favre Bertrand, Plantard Laure, Aeschbach Lorène, Brakch Noureddine, Christen-Zaech Stephanie, de Viragh Pierre A, Sergeant Ann, Huber Marcel, Hohl Daniel

Abstract excerpt

SLURP1 is a secreted member of the LY6/PLAUR protein family. Mutations in the SLURP1 gene are the cause of Mal de Meleda (MDM), a rare autosomal recessive genetic disease, characterized by inflammatory palmoplantar keratoderma. In this study, we have analyzed the expression of SLURP1 in normal and MDM skin. SLURP1 was found to be a marker of late differentiation, predominantly expressed in the granular layer of...

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Source

Identifiers

PMID: 17008884
DOI: 10.1038/sj.jid.5700551

Genes

SLURP1
PLAUR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda.PMID 17008884Read ↗

Abnormal keratinization and cutaneous inflammation in Mal de Meleda.Semantic proximity Read ↗

Palmoplantar Keratoderma in Slurp2-Deficient Mice.Semantic proximity Read ↗

Mutations in the gene encoding SLURP-1 in Mal de Meleda.Semantic proximity Read ↗

Biochemical Basis of Skin Disease Mal de Meleda: SLURP-1 Mutants Differently Affect Keratinocyte Proliferation and Apoptosis.Semantic proximity Read ↗

Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda.Semantic proximity Read ↗

Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice.Semantic proximity Read ↗

SLURP-1 is mutated in Mal de Meleda, a potential molecular signature for melanoma and a putative squamous lineage tumor suppressor gene.Semantic proximity Read ↗

Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates.Semantic proximity Read ↗

Mal de Meleda: A Focused Review.Semantic proximity Read ↗

Identification of novel homozygous SLURP1 mutation in a Javanese family with Mal de Meleda.Semantic proximity Read ↗

Palmoplantar keratoderma of the Gamborg-Nielsen type is caused by mutations in the SLURP1 gene and represents a variant of Mal de Meleda.Semantic proximity Read ↗

Particular Mal de Meleda phenotypes in Tunisia and mutations founder effect in the Mediterranean region.Semantic proximity Read ↗

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