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Article

Palmoplantar Keratoderma in Slurp2-Deficient Mice.

The Journal of investigative dermatology - 1 Feb 2016

Allan Christopher M, Procaccia Shiri, Tran Deanna, Tu Yiping, Barnes Richard H, Larsson Mikael, Allan Bernard B, Young Lorraine C, Hong Cynthia, Tontonoz Peter, Fong Loren G, Young Stephen G, Beigneux Anne P

Abstract excerpt

SLURP1, a member of the lymphocyte antigen 6 protein family, is secreted by suprabasal keratinocytes. Mutations in SLURP1 cause a palmoplantar keratoderma (PPK) known as mal de Meleda. SLURP2, another secreted lymphocyte antigen 6 protein, is encoded by a gene located ?20 kb downstream from SLURP1. SLURP2 is produced by suprabasal keratinocytes. To investigate the importance of SLURP2, we first examined Slurp2...

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Source

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Identifiers

PMID: 26967477
DOI: 10.1016/j.jid.2015.11.003
PMCID: PMC4789766

Genes

SLURP1
SLURP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

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Palmoplantar Keratoderma in Slurp2-Deficient Mice.PMID 26967477Read ↗

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Autosomal dominant SLURP1 variants cause palmoplantar keratoderma and progressive symmetric erythrokeratoderma.Semantic proximity Read ↗

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SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda.Semantic proximity Read ↗

Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda.Semantic proximity Read ↗

The palmoplantar keratodermas: much more than palms and soles.Semantic proximity Read ↗

Identification of novel homozygous SLURP1 mutation in a Javanese family with Mal de Meleda.Semantic proximity Read ↗

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Palmoplantar keratoderma of the Gamborg-Nielsen type is caused by mutations in the SLURP1 gene and represents a variant of Mal de Meleda.Semantic proximity Read ↗

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